Grant title: Circuit Mechanisms of Hypersensitivity to Sensory Distractors in Fragile X Syndrome.
Principal Investigator: Anubhuti Goel
Source: Brain and Behavior Foundation
Summary: The goal of this project is to study the dysfunctional long-range neural dynamics from frontal cortical brain areas and subcortical inputs from the nucleus basalis, to primary visual cortex in a mouse model of Fragile X Syndrome.
Grant title: Targeting of Serotonin 1A receptors during development to reverse neurobehavioral phenotypes in Fmr1 KO mice.
Co-Principal Investigator: Khaleel Razak
Source: FRAXA Research Foundation.
Summary: The goal of the project is to determine whether biased and selective serotonin-1A receptor agonists can reduce auditory hypersensitivity in Fmr1 knockout mice.
Grant title: Sensory plasticity in fathers.
Co-Principal Investigator: Khaleel Razak
Source: National Science Foundation
Summary: This study examines auditory processing in biparental rodent fathers. The goal of the project is to determine whether the auditory cortex shows plasticity for enhanced processing of pup vocalizations, and if responses are also altered by pup specific odor.
Grant title: Using nicotine to reverse age-related auditory processing deficit.
Co-Principal Investigator: Khaleel Razak
Source: National Institutes of Health; National Institute on Aging.
Summary: To test the hypothesis that age-related changes in central auditory processing can be reversed with nicotinergic acetylcholine receptor activation.
Grant title: Translational medicine and mechanistic studies of brain neurophysiology in Fragile X Syndrome.
Co-Principal Investigator: Khaleel Razak
Source: National Institutes of Health; National Institute of Child Health and Human Development; Center for research on FXS
Summary: To identify mechanisms and biomarkers of sensory hypersensitivity in FXS.
Grant title: Sex-specific mechanisms of cortical circuit dysfunction in a mouse ASD model.
Co-Principal Investigator: Khaleel Razak
Source: National Institutes of Health
Summary: To identify mechanisms of sex and genotype differences in sensory processing in a PTEN mouse model of ASD
Grant title: Cortical plasticity within and across lifetimes.
Co-Principal Investigator: Khaleel Razak
Source: James S. McDonnell Foundation grant.
Summary: Studies of Neocortical Evolution in model systems.
Grant title: Conquering fear and its generalization through synthesis of artificial memory traces.
Principal Investigator: Ed Korzus
Source: Department Of Army Research
Summary: To investigate prefrontal circuit dynamics guiding fear modulation using calcium imaging in freely behaving animals.
Grant title: Prefrontal network dynamics associated with learning to control fear.
Principal Investigator: Ed Korzus
Summary: To investigate prefrontal network biomarkers of fear generalization.
Grant title: The role of prefrontal circuitry in fear discrimination learning
Principal Investigator: Ed Korzus
Source: Brain & Behavior Research Foundation
Summary: To provide insights into how the prefrontal circuit supports fear modulation.
Grant title: Cortical Feedback Modulation of Sensory Processing During Selective Detection
Principal Investigator: Edward Zagha
Source: National Institutes of Health; National Institute of Neurological Disorders and Stroke
Summary: To understand the neural mechanisms by which cortical feedback pathways modulate sensory signals according to task demands.